After the initial injection, there may be pain and soreness for the next few days at the site of injury. For a few days before the injection and for the week after the injection, it is critical to avoid anti-inflammatory medications, including Advil, Motrin, ibuprofen, Aleve, Celebrex, and aspirin (unless prescribed by your heart doctor). These will interfere with and delay the healing response. Tylenol is OK. Your doctor may prescribe pain medication also.